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Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis remedy | Journal of Nanobiotechnology


  • Shivaji UN, Nardone OM, Cannatelli R, Smith SC, Ghosh S, Iacucci M. Small molecule oral focused therapies in ulcerative colitis. Lancet Gastroenterol. 2020;5:850–61.


    Google Scholar
     

  • Prados ME, Garcia-Martin A, Unciti-Broceta JD, Palomares B, Collado JA, Minassi A, et al. Betulinic acid hydroxamate prevents colonic irritation and fibrosis in murine fashions of inflammatory bowel illness. Acta Pharmacol Sin. 2021;42:1124–38.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Kobayashi T, Siegmund B, Le Berre C, Wei SC, Ferrante M, Shen B, et al. Ulcerative colitis. Nat Rev Dis Primers. 2020;6:74.

    PubMed 
    Article 

    Google Scholar
     

  • Chung CH, Jung W, Keum H, Kim TW, Jon S. Nanoparticles derived from the pure antioxidant rosmarinic acid ameliorate acute inflammatory bowel illness. ACS Nano. 2020;14:6887–96.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Neurath MF. Cytokines in inflammatory bowel illness. Nat Rev Immunol. 2014;14:329–42.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Na YR, Stakenborg M, Seok SH, Matteoli G. Macrophages in intestinal irritation and backbone: a possible therapeutic goal in IBD. Nat Rev Gastro Hepat. 2019;16:531–43.

    CAS 
    Article 

    Google Scholar
     

  • Soehnlein O, Steffens S, Hidalgo A, Weber C. Neutrophils as protagonists and targets in persistent irritation. Nat Rev Immunol. 2017;17:248–61.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Zhang S, Langer R, Traverso G. Nanoparticulate drug supply techniques concentrating on irritation for remedy of inflammatory bowel illness. Nano At the moment. 2017;16:82–96.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Zhang S, Ermann J, Succi MD, Zhou A, Hamilton MJ, Cao BN, et al. An inflammation-targeting hydrogel for native drug supply in inflammatory bowel illness. Sci Transl Med. 2015;7:300ra128.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Torres J, Danese S, Colombel JF. New therapeutic avenues in ulcerative colitis: considering out of the field. Intestine. 2013;62:1642–52.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Yang C, Merlin D. Nanoparticle-mediated drug supply techniques for the remedy of IBD: present views. Int J Nanomed. 2019;14:8875–89.

    CAS 
    Article 

    Google Scholar
     

  • Yang M, Zhang Y, Ma Y, Yan X, Gong L, Zhang M, et al. Nanoparticle-based therapeutics of inflammatory bowel illnesses: a story overview of the present state and prospects. J Bio-X Res. 2020;3:157–73.


    Google Scholar
     

  • Zeng Z, He X, Li C, Lin S, Chen H, Liu L, et al. Oral supply of antioxidant enzymes for efficient remedy of inflammatory illness. Biomaterials. 2021;271: 120753.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Han W, Xie B, Li Y, Shi L, Wan J, Chen X, et al. Orally deliverable nanotherapeutics for the synergistic remedy of colitis-associated colorectal most cancers. Theranostics. 2019;9:7458–73.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Zhang M, Xu C, Liu D, Han M, Wang L, Merlin D. Oral supply of nanoparticles loaded with ginger energetic compound, 6-shogaol, attenuates ulcerative colitis and promotes wound therapeutic in a murine mannequin of ulcerative colitis. J Crohns Colitis. 2018;12:217–29.

    PubMed 
    Article 

    Google Scholar
     

  • Li C, Li L, Chen S, Zhang J, Lu W. Antioxidant nanotherapies for the remedy of inflammatory illnesses. Entrance Bioeng Biotech. 2020;8:200.

    CAS 
    Article 

    Google Scholar
     

  • Liu Y, Cheng Y, Zhang H, Zhou M, Yu Y, Lin S, et al. Built-in cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory remedy. Sci Adv. 2020;6:eabb2695.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Ren Q, Solar S, Zhang X. Redox-active nanoparticles for inflammatory bowel illness. Nano Res. 2021;14:2535–57.

    CAS 
    Article 

    Google Scholar
     

  • Yang M, Zhang F, Yang C, Wang L, Sung J, Garg P, et al. Oral focused supply by nanoparticles enhances efficacy of an Hsp90 inhibitor by lowering systemic publicity in murine fashions of colitis and colitis-associated most cancers. J Crohns Colitis. 2020;14:130–41.

    PubMed 
    Article 

    Google Scholar
     

  • Li C, Zhao Y, Cheng J, Guo J, Zhang Q, Zhang X, et al. A Proresolving peptide nanotherapy for site-specific remedy of inflammatory bowel illness by regulating proinflammatory microenvironment and intestine microbiota. Adv Sci. 2019;6:1900610.

    CAS 
    Article 

    Google Scholar
     

  • Zhang M, Xu C, Wen L, Han M, Xiao B, Zhou J, et al. A hyaluronidase-responsive nanoparticle-based drug supply system for concentrating on colon most cancers cells. Most cancers Res. 2016;76:7208–18.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Liang C, Bai X, Qi C, Solar Q, Han X, Lan T, et al. Π electron-stabilized polymeric micelles potentiate docetaxel remedy in advanced-stage gastrointestinal most cancers. Biomaterials. 2021;266: 120432.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Shi H, Zhao X, Gao J, Liu Z, Liu Z, Wang Ok, et al. Acid-resistant ROS-responsive hyperbranched polythioether micelles for ulcerative colitis remedy. Chin Chem Lett. 2020;31:3102–6.

    CAS 
    Article 

    Google Scholar
     

  • Liu P, Gao C, Chen H, Vong CT, Wu X, Tang X, et al. Receptor-mediated focused drug supply techniques for remedy of inflammatory bowel illness: alternatives and rising methods. Acta Pharm Sin B. 2020;11(9):2798–818.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Lei C, Mu J, Teng Y, He L, Xu F, Zhang X, et al. Lemon exosome-like nanoparticles-manipulated probiotics defend mice from C. diff an infection. Iscience. 2020;23:101571.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Hu Q, Lyon CJ, Fletcher JK, Tang W, Wan M, Hu TY. Extracellular vesicle actions regulating macrophage-and tissue-mediated harm and restore responses. Acta Pharm Sin B. 2021;11:1493–512.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Perut F, Roncuzzi L, Avnet S, Massa A, Zini N, Sabbadini S, et al. Strawberry-derived exosome-like nanoparticles stop oxidative stress in human mesenchymal stromal cells. Biomolecules. 2021;11:87.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Yang C, Zhang M, Merlin D. Advances in plant-derived edible nanoparticle-based lipid nano-drug supply techniques as therapeutic nanomedicines. J Mater Chem B. 2018;6:1312–21.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Sreedhar R, Arumugam S, Thandavarayan RA, Karuppagounder V, Watanabe Ok. Curcumin as a therapeutic agent within the chemoprevention of inflammatory bowel illness. Drug Discov At the moment. 2016;21:843–9.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • He Y, Yue Y, Zheng X, Zhang Ok, Chen S, Du Z. Curcumin, irritation, and persistent illnesses: how are they linked? Molecules. 2015;20:9183–213.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Vecchi Brumatti L, Marcuzzi A, Tricarico PM, Zanin V, Girardelli M, Bianco AM. Curcumin and inflammatory bowel illness: potential and limits of progressive therapies. Molecules. 2014;19:21127–53.

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Aggarwal BB, Shishodia S. Molecular targets of dietary brokers for prevention and remedy of most cancers. Biochem Pharmacol. 2006;71:1397–421.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Hsiang CY, Lo HY, Huang HC, Li CC, Wu SL, Ho TY. Ginger extract and zingerone ameliorated trinitrobenzene sulphonic acid-induced colitis in mice through modulation of nuclear factor-κB exercise and interleukin-1β signalling pathway. Meals Chem. 2013;136:170–7.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Maiti P, Dunbar GL. Use of Curcumin, a pure polyphenol for concentrating on molecular pathways in treating age-related neurodegenerative illnesses. Int J Mol Sci. 2018;19:1637.

    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Abo-Zaid MA, Shaheen ES, Ismail AH. Immunomodulatory impact of curcumin on hepatic cirrhosis in experimental rats. J Meals Biochem. 2020;44: e13219.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Memarzia A, Khazdair MR, Behrouz S, Gholamnezhad Z, Jafarnezhad M, Saadat S, et al. Experimental and medical stories on anti-inflammatory, antioxidant, and immunomodulatory results of Curcuma longa and curcumin, an up to date and complete overview. BioFactors. 2021;47(3):311–50.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Moura FA, de Andrade KQ, Dos Santos JC, Araújo OR, Goulart MO. Antioxidant remedy for remedy of inflammatory bowel illness: does it work? Redox Biol. 2015;6:617–39.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Zhang M, Viennois E, Xu C, Merlin D. Plant derived edible nanoparticles as a brand new therapeutic strategy towards illnesses. Tissue Limitations. 2016;4: e1134415.

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Mu J, Zhuang X, Wang Q, Jiang H, Deng Z, Wang B, et al. Interspecies communication between plant and mouse intestine host cells by means of edible plant derived exosome-like nanoparticles. Mol Nutr Meals Res. 2014;58:1561–73.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Deng Z, Rong Y, Teng Y, Mu J, Zhuang X, Tseng M, et al. Broccoli-derived nanoparticle inhibits mouse colitis by activating dendritic cell AMP-activated protein kinase. Mol Ther. 2017;25:1641–54.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Teng Y, Ren Y, Sayed M, Hu X, Lei C, Kumar A, et al. Plant-derived exosomal microRNAs form the intestine microbiota. Cell Host Microbe. 2018;24:637–52.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Zhuang X, Deng Z, Mu J, Zhang L, Yan J, Miller D, et al. Ginger-derived nanoparticles defend towards alcohol-induced liver injury. J Extracell Vesicles. 2015;4:28713.

    PubMed 
    Article 
    CAS 

    Google Scholar
     

  • Zhang M, Viennois E, Prasad M, Zhang Y, Wang L, Zhang Z, et al. Edible ginger-derived nanoparticles: a novel therapeutic strategy for the prevention and remedy of inflammatory bowel illness and colitis-associated most cancers. Biomaterials. 2016;101:321–40.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Sung J, Yang C, Viennois E, Zhang M, Merlin D. Isolation, purification, and characterization of ginger-derived nanoparticles (GDNPs) from ginger, rhizome of Zingiber officinale. Bio-Protoc. 2019;9: e3390.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Konoshenko MY, Lekchnov EA, Vlassov AV, Laktionov PP. Isolation of extracellular vesicles: common methodologies and newest developments. BioMed Res Int. 2018;2018:8545347.

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Witwer KW, Buzás EI, Bemis LT, Bora A, Lässer C, Lötvall J, et al. Standardization of pattern assortment, isolation and evaluation strategies in extracellular vesicle analysis. J Extracell Vesicles. 2013;2:20360.

    Article 
    CAS 

    Google Scholar
     

  • Jones N, Blagih J, Zani F, Rees A, Hill DG, Jenkins BJ, et al. Fructose reprogrammes glutamine-dependent oxidative metabolism to help LPS-induced irritation. Nat Commun. 2021;12:1–13.

    Article 
    CAS 

    Google Scholar
     

  • Linghu KG, Ma Q, Zhao G, Xiong W, Lin L, Zhang Q, et al. Leocarpinolide B attenuates LPS-induced irritation on RAW264.7 macrophages by mediating NF-κB and Nrf2 pathways. Eur J Pharmacol. 2020;868:172854.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Li S, Xie A, Li H, Zou X, Zhang Q. A self-assembled, ROS-responsive Janus-prodrug for focused remedy of inflammatory bowel illness. J Management Launch. 2019;316:66–78.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Xu J, Zhang Y, Xu J, Wang M, Liu G, Wang J, et al. Reversing tumor stemness through orally focused nanoparticles achieves environment friendly colon most cancers remedy. Biomaterials. 2019;216: 119247.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Fasolino I, Izzo AA, Clavel T, Romano B, Haller D, Borrelli F. Orally administered allyl sulfides from garlic ameliorate murine colitis. Mol Nutr Meals Res. 2015;59:434–42.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Wu C, Wu Y, Jin Y, Zhu P, Shi W, Li J, et al. Endosomal/lysosomal location of organically modified silica nanoparticles following caveolae-mediated endocytosis. RSC Adv. 2019;9:13855–62.

    CAS 
    Article 

    Google Scholar
     

  • Zhang Y, Commisso C. Macropinocytosis in most cancers: a fancy signaling community. Developments Most cancers. 2019;5:332–4.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Kim SH, Cho SN, Lim YJ, Choi JA, Lee J, Go D, et al. Phagocytosis influences the intracellular survival of Mycobacterium smegmatis through the endoplasmic reticulum stress response. Cell Biosci. 2018;8:1–11.

    Article 
    CAS 

    Google Scholar
     

  • Oh JM, Choi SJ, Kim ST, Choy JH. Mobile uptake mechanism of an inorganic nanovehicle and its drug conjugates: enhanced efficacy on account of clathrin-mediated endocytosis. Bioconjugate Chem. 2006;17:1411–7.

    CAS 
    Article 

    Google Scholar
     

  • Zhao H, Cheng N, Zhou W, Chen S, Wang Q, Gao H, et al. Honey polyphenols ameliorate DSS-induced ulcerative colitis through modulating intestine microbiota in rats. Mol Nutr Meals Res. 2019;63:1900638.

    CAS 
    Article 

    Google Scholar
     

  • Yang C, Zhang M, Lama S, Wang L, Merlin D. Pure-lipid nanoparticle-based therapeutic strategy to ship 6-shogaol and its metabolites M2 and M13 to the colon to deal with ulcerative colitis. J Management Launch. 2020;323:293–310.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Xu X, An H, Zhang D, Tao H, Dou Y, Li X, et al. A self-illuminating nanoparticle for irritation imaging and most cancers remedy. Sci Adv. 2019;5:eaat2953.

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Li H, Feng C, Fan C, Yang Y, Yang X, Lu H, et al. Intervention of oncostatin M-driven mucosal irritation by berberine exerts therapeutic property in persistent ulcerative colitis. Cell Demise Dis. 2020;11:271.

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Arango Duque G, Descoteaux A. Macrophage cytokines: involvement in immunity and infectious illnesses. Entrance Immunol. 2014;5:491.

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar
     

  • Yan Y, Shao M, Qi Q, Xu Y, Yang X, Zhu F, et al. Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis through suppressing neutrophils and macrophages. Acta Pharmacol Sin. 2018;39:1633–44.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Kim YJ, Kim EH, Hahm KB. Oxidative stress in inflammation-based gastrointestinal tract illnesses: challenges and alternatives. J Gastroen Hepatol. 2012;27:1004–10.

    CAS 
    Article 

    Google Scholar
     

  • Dickinson BC, Chang CJ. Chemistry and biology of reactive oxygen species in signaling or stress responses. Nat Chem Biol. 2011;7:504.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Campbell NK, Fitzgerald HK, Dunne A. Regulation of irritation by the antioxidant haem oxygenase 1. Nat Rev Immunol. 2021;21:1–15.

    Article 
    CAS 

    Google Scholar
     

  • Waza AA, Hamid Z, Ali S, Bhat SA, Bhat MA. A overview on heme oxygenase-1 induction: is it a vital evil. Inflamm Res. 2018;67:579–88.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Daulagala AC, Bridges MC, Kourtidis A. E-cadherin past construction: a signaling hub in colon homeostasis and illness. Int J Mol Sci. 2019;20:2756.

    CAS 
    PubMed Central 
    Article 

    Google Scholar
     

  • Ghosh S, Whitley CS, Haribabu B, Jala VR. Regulation of intestinal barrier perform by microbial metabolites. Cell Mol Gastroenter. 2021;11:1463–82.


    Google Scholar
     

  • Terciolo C, Dobric A, Ouaissi M, Siret C, Breuzard G, Silvy F, et al. Saccharomyces boulardii CNCM I-745 restores intestinal barrier integrity by regulation of E-cadherin recycling. J Crohns Colitis. 2017;11:999–1010.

    PubMed 
    Article 

    Google Scholar
     

  • Cavallini F, Tarantola M. ECIS based mostly wounding and reorganization of cardiomyocytes and fibroblasts in co-cultures. Prog Biophys Mol Bio. 2019;144:116–27.

    CAS 
    Article 

    Google Scholar
     

  • Merlin-Zhang O, Sung J, Viennois E. In vitro intestinal epithelial wound-healing assays utilizing Electrical Cell-Substrate Impedance Sensing Instrument. Bio-Protoc. 2019;9: e3351.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Bronte V, Pittet MJ. The spleen in native and systemic regulation of immunity. Immunity. 2013;39:806–18.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Wang S, Liu X, Wang Y, Xu D, Liang C, Guo J, et al. Biocompatibility of synthetic micro/nanomotors to be used in biomedicine. Nanoscale. 2019;11:14099–112.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Williams DF. On the mechanisms of biocompatibility. Biomaterials. 2008;29:2941–53.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Kou J, Wang M, Shi J, Zhang H, Pu X, Tune S, et al. Curcumin reduces cognitive deficits by inhibiting neuroinflammation by means of the endoplasmic reticulum stress pathway in apolipoprotein E4 transgenic mice. ACS Omega. 2021;6:6654–62.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Buhrmann C, Mobasheri A, Busch F, Aldinger C, Stahlmann R, Montaseri A, et al. Curcumin modulates nuclear factor-κB (nf-κB)-mediated irritation in human tenocytes in vitro: position of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem. 2011;286:28556–66.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Viennois E, Xiao B, Ayyadurai S, Wang L, Wang P, Zhang Q, et al. Micheliolide, a brand new sesquiterpene lactone that inhibits intestinal irritation and colitis-associated most cancers. Lab Investig. 2014;94:950–65.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Lee SH, Bajracharya R, Min JY, Han JW, Park BJ, Han HK. Strategic approaches for colon focused drug supply: an outline of latest developments. Pharmaceutics. 2020;12:68.

    CAS 
    PubMed Central 
    Article 

    Google Scholar
     

  • Zhang M, Merlin D. Nanoparticle-based oral drug supply techniques concentrating on the colon for remedy of ulcerative colitis. Inflamm Bowel Dis. 2018;24:1401–15.

    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Sundaram Ok, Miller DP, Kumar A, Teng Y, Sayed M, Mu J, et al. Plant-derived exosomal nanoparticles inhibit pathogenicity of Porphyromonas gingivalis. Iscience. 2019;21:308–27.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Tirosh B, Khatib N, Barenholz Y, Nissan A, Rubinstein A. Transferrin as a luminal goal for negatively charged liposomes within the infected colonic mucosa. Mol Pharmaceut. 2009;6:1083–91.

    CAS 
    Article 

    Google Scholar
     

  • Ehehalt R, Wagenblast J, Erben G, Lehmann WD, Hinz U, Merle U, et al. Phosphatidylcholine and lysophosphatidylcholine in intestinal mucus of ulcerative colitis sufferers. A quantitative strategy by nanoelectrospray-tandem mass spectrometry. Scand J Gastroenterol. 2004;39:737–42.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Ju S, Mu J, Dokland T, Zhuang X, Wang Q, Jiang H, et al. Grape exosome-like nanoparticles induce intestinal stem cells and defend mice from DSS-induced colitis. Mol Ther. 2013;21:1345–57.

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar
     

  • Zhuang X, Teng Y, Samykutty A, Mu J, Deng Z, Zhang L, et al. Grapefruit-derived nanovectors delivering therapeutic miR17 by means of an intranasal route inhibit mind tumor development. Mol Ther. 2016;24:96–105.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Castanheira FV, Kubes P. Neutrophils and NETs in modulating acute and persistent irritation. Blood. 2019;133:2178–85.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

  • Fullerton JN, Gilroy DW. Decision of irritation: a brand new therapeutic frontier. Nat Rev Drug Discov. 2016;15:551.

    CAS 
    PubMed 
    Article 

    Google Scholar
     

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